• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    OCLUSOR TO OCLUDE A PASSAGE IN A CIRCULATORY SYSTEM. Occlusor to occlude a passageway in a circulatory system comprising at least one occluding body (4) to occlude the passageway, an expanding unit (1) comprising at least one fixing structure for securing the occlusive body (4,5) within the passageway , and at least a part of the expansion unit (1) expands into said fixation structure, thereby expanding the occluding body and a locking unit (2,3) to lock the expansion unit (1) in its expanded state . The expansion unit (1) comprises a first and a second end, the first end being connected to a first element of the locking unit (2,3) and the second end being connected to a second element of the locking unit (2 , 3), the first and second elements of the locking unit (2,3) being placed in locking engagement with each other when the occluding body (4,5) is expanded, the occlusion also comprising a jacket (6,7) which involves at least a part of the expansion unit (1). This occluder prevents any part of the occluder from migrating within the human or animal body and increases the growth of body tissue over the occlusor.
    公开号:BR112013029223B1
    申请号:R112013029223-7
    申请日:2012-05-15
    公开日:2020-10-13
    发明作者:Andreas Weishaupt；Jérôme Bernhard
    申请人:Carag Ag；
    IPC主号:
    专利说明:

    Technical field
    [0001] The present invention relates to an occluder to occlude a passage in a circulatory system and more particularly to close a passage in a human body, for example, an opening through an atrial septum or ventricular septum of a heart or of a body channel. State of the art
    [0002] WO 03/032818 describes an umbrella style occlusor, that is, it is automatically operated as soon as it leaves its implantation catheter. It comprises an occlusive member with a structure and a barrier. The structure consists of a plurality of radii that extend radially outward. The barrier comprises two layers, one on each side of the structure.
    [0003] WO 2005/034723 shows an occluder with two candle-type occluding bodies, each disposed on a ring. Arms connect the two rings to a central column. The arms have a shape memory so that the occluder is automatically operated in its desired shape.
    [0004] EP 0 474 887 also describes a self-expanding candle-type occluder with two adhesives, each comprising a tissue sheet arranged on a resilient annular frame. The two adhesives are arranged face to face with a gap between them and concentrically sewn together in an outside-in position from the outer periphery of each adhesive. When you pull a line that appears on one of the stickers, the two stickers come close to each other.
    [0005] EP 1 149 561 describes a spring-type septal defect occluder with two occlusive panels. Each occlusion panel includes a support structure in fabric and fabric suspended from it.
    [0006] WO 01/49185 shows a spring-type occluder with shoelaces connecting elongated spring members.
    [0007] WO 97/16119 relates to an umbrella-like self-centering septal closure device that includes a proximal and distal occluder, each having a plurality of arms supporting occlusion bodies. Each of the proximal and distal support arms has at least three spirals.
    [0008] US patent 4,836,204 shows a double balloon septal defect occlusion catheter, used to temporarily close septal perforations, allowing surgical closure of the defect at a later date.
    [0009] US patent 3 874 388 describes an occluder with two umbrellas, in which each opens individually, the umbrellas being gathered and locked together in a passage of the human body.
    [0010] WO 2010/151509 describes an occluder with expandable structure consisting of wires extending from a proximal end to a distal end of the structure. The wires form a proximal eye and a distal eye. The occluder further comprises a sealing member partially encapsulating the expandable wire structure. This sealing member is formed by sheets of fine material adhered to the structure by means of adhesive.
    [0011] US patent 2008/0077180 shows an occluder with a support structure ("scaffold") of fabric that encapsulates the petals of the occluder. This fabric support structure is used to improve the seal of the opening when closed.
    [0012] An implant of satisfactory operation to occlude a passage in a circulatory system is described in US patent 6 488 706. This implant has specific application as a cardiological implant, through which it is possible, for example, to occlude an opening through the septum atrial or ventricular septum of a heart. It is willing to be driven or built in a desired location on the body, unlike other known implants that, in turn, expand as soon as a compressed umbrella or compressed candle leaves its insertion catheter. This occluder comprises a plurality of thin elongated wire-shaped members that form a fixation structure and a simple occlusion body, namely, a flexible disk-shaped membrane, which is expanded through the fixation structure in the passage of the body. The fastening structure is locked in its expanded state by a locking unit. This locking unit comprises two locking elements that come together when the occluding body is expanded.
    [0013] WO 2005/074813 describes an occluder that operates on the same principle, but which comprises two occluding bodies that are expanded by the fastening structure. This occluder securely closes the two sides of the passage.
    [0014] The last two mentioned occlusors have the advantage of being able to be opened and closed and, therefore, their location within the body passage can be changed until the fixation structure is locked in its expanded form by the blocking unit. However, care must be taken that the thin, elongated members do not break, especially when bent into the fixation structure. When using biodegradable material, as suggested in US patent 2003/0149463, care must be taken so that the implant is not covered by exacerbated growth of body tissue, before the material is dissolved. Small parts that can detach themselves from the occluder and migrate to other parts of the body, can cause serious damage. In addition, it has been observed that exacerbated growth over the occlusive body, especially of the disk-shaped membranes, occurs more rapidly than exacerbated growth over the elongated limbs. Summary of the invention
    [0015] The object of the invention is, therefore, to provide an improved occluder.
    [0016] This object is achieved with an occluder as defined in claim 1.
    [0017] The occluder of the invention, to occlude a passage in a circulatory system, comprises at least one occluding body to occlude the passage, an expansion unit comprising at least one fixation structure to fix the occlusive body within the passage, at least at least a part of the expansion unit expands into said fixing structure, thereby expanding the occluding body and a locking unit to lock the expansion unit in its expanded state, the expansion unit comprising a first and a second end and being that the first end is connected to a first element of the locking unit and the second end is connected to a second element of the locking unit, the first and second elements of the locking unit being placed in locking engagement with each other when the occluding body is expanded, the occluder further comprising a jacket that involves at least a part of the expanding unit.
    [0018] If the expansion unit is a multiple of elongated members, such as filaments, lines or threads, the outer jacket can envelop a multiple or all of these elongated members, that is, a bundle of them. They can also be a multiple of shirts and each elongated member or at least some of these elongated members are each enveloped with a separate shirt. In another embodiment, the elongated members are individually wrapped in part of their length or in their entire length, and are also bundled with additional sleeves. For example, the fixation structures are wrapped as a whole and the remaining parts of the members elongated between the two membranes or occlusive bodies are individually enveloped.
    [0019] The occluder, according to the invention, comprises a protective jacket or jacket at least for the fixing structure. This casing is made of soft and / or flexible material, so that it can also be compressed or folded when the occluder is inserted into an introduction shirt in the animal or human body. This shirt contours and wraps around the fixing structure. Preferably, it is always arranged around that part of the expansion unit, even before the fixation structure is formed, that is, before the occluder is expanded.
    [0020] When the parts of the fixation structure break, they are prevented by the shirt from moving through the body. This is another advantage, because if the cavity containing the shirt is filled with coagulated blood, the fixation structure is retained and the broken parts do not move.
    [0021] In a preferred embodiment, the jacket bypasses the fixing structure in its circumference around the longitudinal geometric axis of the occluder. In another preferred embodiment, the jacket outlines simple parts of the expanding unit. If the expanding unit consists of elongated members, such as filaments, each or at least some of the elongated members can be encapsulated in a jacket over its entire length or along a part of its length.
    [0022] In all embodiments, the shirt can be made of tight / tight material or it can also have openings. For example, it can be a network, mesh fabric, fabric or fused membrane.
    [0023] Another advantage is that the shirt, shirt or envelope increases the endothelialization or exacerbated growth of occluder and fabric, since the tissue cells prefer the material of the shirt more than the material of the fixation structure. This increases the growth of the occluder, especially in embodiments where the fixation structure adapts its shape to the tissue that bypasses the passage in the human or animal body.
    [0024] The preferred material for the shirt is polyester or degradable polymer such as PLA, PLLA, PGA, PLGA or P4HB or a mixture of those polymeric materials. The preferred material for the fastening structure is metal or a degradable polymer such as PLA, PLLA, PGA, PLGA or P4HB or a mixture of those polymeric materials. The occluding body is preferably made of the same material as the jacket. However, it can also be made with different material. Preferred materials for the occluding body are polyester or degradable polymer, such as PLA, PLLA, PGA, PLGA or P4HB or a mixture of those polymeric materials. The occluding body is preferably made of flexible sheet. Preferably, it has a circular disk format when expanded.
    [0025] When an occluder with two liners is used, the liners can be made of different materials. For example, one may be biodegradable and the other may not. The same applies to fastening structures and occluding bodies.
    [0026] When the jacket is made of biodegradable material, the fixing structure is also preferably made of biodegradable material. In a preferred embodiment, the degradation rate of the jacket is less than that of the fixation structure so that the fixation structure is protected by the jacket until it is well dissolved or the occluder shows exacerbated growth.
    [0027] In a preferred embodiment of the invention, the occluder comprises exactly two fixing structures and two external liners, each liner enveloping one of the fixing structures. Such an embodiment may comprise a single occlusive body or two occlusive bodies.
    [0028] In a preferred embodiment, the occluder comprises exactly a first and a second occluding body, the first and the second occluding bodies being arranged at a certain distance from each other, the first of which is said fixing structures between the first blocking body and the first element of the locking unit and a second of said fastening structures is disposed between the second blocking body and the second element of the locking unit. This arrangement allows a safe closing of the two sides of the passage.
    [0029] The expansion unit can be prepared in different formats and embodiments. Preferably the expanding unit comprises a plurality of elongated members such as filaments or threads, with first and second ends each, the first end of each elongated member being connected to a first element of the locking unit and the second end of each elongated member being connected to a second element of the locking unit and these elongated members being twisted to form at least one fastening structure. Preferably, the occluder is prepared according to those described in US patent 6 488 706, WO 2005/074813 and US 2003/0149463.
    [0030] Preferably, the expansion unit is movable in relation to the surrounding jacket. Like this, the fixation structure can be built inside its housing without interference during expansion.
    [0031] Preferably, the jacket is connected to at least some of the elongated members, the elongated members comprising a longitudinal geometric axis each and the elongated members being able to move in relation to the shirt in the direction of its corresponding longitudinal geometric axis. Like this, the fixation structure does not suffer interference during the expansion, ensuring that the jacket outlines the structure safely when built. Sewing the shirt over at least some of the longitudinal members is a simple way to obtain a secure, yet loose, connection between the fixing structure and the shirt.
    [0032] In a preferred embodiment, the fastening structure is expanded within the shirt, although it does not penetrate the shirt material.
    [0033] Preferably, the jacket is connected to the occluding body. The occluding body can form one side of the shirt. In one embodiment, the occluding body has a circumferential edge and the jacket is attached to that edge. This connection does not have to be leakproof (watertight), but it may contain holes or openings. For example, the shirt can be sewn on the occluding body, welded on it, glued to it or otherwise connected. It is also possible that the occluding body and the jacket are made with a simple unitary part. However, in all embodiments, it is preferred that the occluder body is rounded and approximately flat in disc shape when the occluder is expanded. The jacket and the occluding body are preferably made of flexible material, the occluding body and the jacket being compressible in a folded state.
    [0034] Other embodiments of the invention are shown in the dependent claims. Brief description of the drawings
    [0035] The preferred embodiments of the invention are described below with reference to the drawings, which serve to illustrate the preferred embodiments of the invention and which are not intended to restrict its scope. In the drawings:
    [0036] Figure 1 shows a partial sectional view of an occluder according to the invention in an expanded state in a first embodiment;
    [0037] Figure 2 shows a side view of the occluder according to Figure 1;
    [0038] Figure 3 shows a longitudinal section of the occluder according to claim 1;
    [0039] Figure 4 shows the occluder according to Figure 1 in an almost completely compressed state;
    [0040] Figure 5 shows an occluder according to Figure 1 in a partially driven and expanded state in longitudinal section;
    [0041] Figure 6 shows the occluder according to Figure 5 in perspective view;
    [0042] Figure 7 shows the occluder according to Figure 5 in partial longitudinal section;
    [0043] Figure 8 shows an occluder according to Figure 1, in a more driven state compared to Figure 5;
    [0044] Figure 9 shows the occluder according to Figure 8 in partial longitudinal section;
    [0045] Figure 10 shows an occluder of the invention according to a second embodiment;
    [0046] Figure 11 shows an inventive occluder according to a third embodiment;
    [0047] Figure 12 shows a photo of the inventive occluder according to the first embodiment;
    [0048] Figure 13 shows an inventive occluder according to a fourth embodiment, in a partially driven state and expanded in longitudinal section;
    [0049] Figure 14 shows the occluder according to Figure 13 in perspective view; and
    [0050] Figure 15 shows the occluder according to Figure 13 without a shirt and an occluding body. Description of preferred embodiments
    [0051] The occluder, according to preferred embodiments, is based on the implants described in WO 2005/074813. However, it can also be based on an occluder, as described in US patents 6 488 706 and US 2004/0149463, that is, an occluder with simple occluding body. The occluder, according to the invention, can also have another shape and operate in another way, as described below.
    [0052] The occluder, according to Figures 1 to 9, is used as an implant to close an internal passage, for example, an opening in the atrial septum or ventricular septum of a heart, a left atrial appendage or in another canal of human or animal body to be closed, the implant being compressible for insertion through a release mechanism, such as an introduction shirt placed in a vein, artery or body vessel, being actionable and expandable to occlude the passage in the circulatory system when it reaches the position of the desired closing point.
    [0053] The occluder comprises at least one, here two occluding bodies 4, 5, and an expansion unit 1 and a locking unit 2,3, as can be seen in Figures 1 to 3.
    [0054] The expanding unit consists of a plurality of thin elongated members 1. These elongated members 1 are in the form of filaments, threads or lines. They are flexible and can be bent, but preferably have no elasticity in the direction of their longitudinal geometric axis. They are preferably rigid and inextensible. Each elongated member has a first end that is connected to or retained in a first support 2 and a second end, which is connected to or retained in a second support 3. The elongated members 1 are arranged separately from each other, not being directly connected to one the other; that is, they are preferably separate wires, not part of a network, nor being otherwise connected.
    [0055] When the two supports 2, 3 are joined, the elongated members 1 compress longitudinally. They automatically bend and twist to the sides, forming two circular or spiral shapes, similar to a flower, a propeller or an umbrella. These twisted shapes form the fixing structures. When the occluder is implanted, these structures extend over the surrounding tissue on both sides of the passage to be closed and fix the occluder in that position.
    [0056] The two supports 2,3 have locking elements that lock the occluder in this expanded format and, therefore, lock the fixing structures in their formats. A locking element is best seen in Figure 9. It is a locking rod 20 of the first support 2, which can be engaged with an opening in the second support 3. This situation is best observed in Figure 3.
    [0057] The first and second occlusive bodies 4,5 are thin membranes, located between the two supports 2,3. In their expanded format, they are preferably rounded, disk-shaped and almost flat. They are made of flexible material, so that they can be folded or compressed when inserted in the introduction jacket. In the expanded and activated state of the occluder, they are also extended. Preferably, they are almost flat, but are generally not stretched in that position, so that they can confine with the surrounding tissue of the passage to be closed. In the figures, the occlusive bodies appear to be completely rigid and their compressed and flexible shape is not realistically shown. Figures 1 and 2 especially should not be understood as if the membranes 4,5 and the jackets 6,7 (which will be described later) were expanded. In addition, in the situations shown in Figures 4 to 9, the two membranes 4,5 are realistically more folded and less flat in a disk shape. The photo according to Figure 12 shows the real occluder. The seams 60 and 70 that divide the membranes 4,5 of the liners 6,7 can also be seen. Preferably, the two occlusive bodies 4,5 are made of the same material and preferably have the same size and shape.
    [0058] The occlusive bodies 4,5 extend radially from the longitudinal geometric axis of the elongated members 1. Preferably, they are arranged concentrically in relation to that geometric axis. Also preferably, the two membranes are identical, their distance to the neighboring support 2,3 being identical. Each occlusion body 4,5 comprises a central hole 40, 50. These holes 40, 50, as well as the corresponding holes in the two supports 2,3 are penetrated by a guide wire when the occlusion is introduced with the introduction jacket in the body passage .
    [0059] The occlusive bodies 4,5 comprise, in their circumference, a substantial distance in relation to their circumferential edge, holes that are penetrated by the elongated members 1. This can be better observed in Figures 5 and 6. The holes are preferably arranged at uniform distances from each other. The elongated members 1 preferably comprise adapter sleeves 10 on both sides of the membranes 4,5, allowing the membranes 4,5 to move only a short distance along the elongated members 1. These sleeves 10 can also be used as markers X-rays, especially when the elongated members are invisible to X-rays. The bushings 10 are preferably made of metal, such as platinum-iridium or degradable material, but visible to X-rays, such as a polymer mixture with BaS.
    [0060] The occlusive bodies 4,5 divide each of the elongated members 1 into three portions. A first portion is located between the first support 2 and the first membrane 4. A second portion is located between the two membranes 4,5 and the third portion is located between the second membrane 5 and the second support 3. The first and the third portions form, in the expanded and twisted position, the first and second fixing structures. The second portion, in its state, has a spiral shape, as can be seen in Figure 2. Preferably, at least the first and third portions of the elongated members 1 are of the same length.
    [0061] According to the invention, each fixing structure in the shape of a flower is individually contoured by its own protective shirt 6.7 or wrapper. A first shirt 6, which is preferably a sleeve, is arranged around the first portion of the elongated members 1 and the second preferably identical shirt 7 is arranged around the third portion of the elongated members 1, which can be better seen in figures 4 , 6, 8 and 9.
    [0062] The elongated members 1 can move in relation to the shirts 6,7. However, to fix the position of the jackets 6, 7 so that they are always on the first and third portions, the jackets 6,7 are loosely connected to at least some of the elongated members 1 in that region. This is done in this example using lines 8,9, so that shirts 6,7 are sewn to the elongated members 1. This can be better observed in figures 5, 7 and 9.
    [0063] The 6.7 shirts themselves can be made in one piece or can comprise several parts that are connected to each other. In this example, each shirt is made in one piece and nailed to membranes 4,5 through seams 60, 70.
    [0064] The liners 6,7 are also connected to the membranes 4,5, with the membranes 4,5 forming a lateral face of the liners 6,7. Preferably, the liners 6,7 are sewn to the membranes 4,5 to form a closed envelope or flexible wrapper that opens only to very small central holes on each side that are penetrated by the elongated members 1. Each of the occlusive bodies 4, 5, however, always preferably forms a roughly flat element when activated and expanded, so that the occlusive bodies 4,5 can smoothly confine with the surrounding tissue of the passage and close the passage in the most appropriate way.
    [0065] As can be seen in Figures 1 and 3, the fixing structures are enclosed within the casing formed by the liners 6,7 and the membranes 4,5. However, the fixation structure can still adapt its shape to the anatomical contour of the passage to be closed. As can be seen in Figures 4 to 9, the parts of the expansion unit, that is, the elongated members 1, which form the fixing structure in the expanded state, are also enclosed in these enclosures in the compressed or partially driven state.
    [0066] Figure 10 shows the inventive occluder according to a second embodiment. The elongated members 1 are enveloped in each shirt 6 'and 7'. The liners 6 'are arranged between the first support 2 and the first membrane 4. The second liner 7' are arranged between the second support 3 and the second membrane 5. Between the two membranes 4,5, the elongated members 1 are free and not encapsulated. Preferably, the elongated members 1 can still move freely with respect to the sleeves 6 ', 7'.
    [0067] Figure 11 shows a third embodiment of the inventive occluder. Here, a long sleeve 6 "extending from the first to the second support 2,3 encapsulates at least approximately the entire length of each elongated member 1. The bushings 10 are also encapsulated within that shirt. Again, the elongated member 1 can still preferably move in relation to that 6 "shirt in its longitudinal direction. The 6 "long jacket can also be made in more than one component, being, for example, composed of three parts so that the jacket is divided into three parts by the two membranes 4,5.
    [0068] Figures 13 to 15 show a fourth embodiment of the inventive occluder. This embodiment comprises the first and second liners 6,7 enveloping the two fixing structures on the distal and proximal side of the occluder. These shirts 6,7 are sleeves, arranged around the first and third portion of the bundle of elongated members 1. Shirts 6,7 are preferably sewn to the elongated members 1 and the membranes 4,5. In addition, this embodiment comprises a multiple of third 6 "jackets, arranged between the first and second membranes 4,5, with these third 6 'jackets each surrounding a simple elongated member 1'. As can be seen best in Figure 15, they preferably wrap only the elongated members 1 partially, that is, only between the two membranes 4,5 Preferably, they are held in place by the lines 10 or by the membranes 4,5 The remaining parts of the elongated members 1 are bundled by the first and second liners 6,7.
    [0069] The occluder, according to the invention, prevents any part of the occluder from migrating to other parts of the human or animal body, and increases the growth of body tissue over the occluder. Reference List 1 elongated member 10 adapter sleeve 2 first support 20 locking rod 3 second support 4 first membrane 40 central hole 5 second membrane 50 central hole 6 first jacket 60 seam 7 second jacket 70 seam 8 first row 9 second row
    权利要求:
    Claims (13)
    [0001]
    1. Occlusor to occlude a passageway in a circulatory system, the occluder comprising at least one occluding body (4,5) to occlude the passageway, an expansion unit (1) comprising at least one fixing structure for securing the occluder within the passageway , and at least a part of the expansion unit (1) expands into said fixation structure, thereby expanding the occluding body and a locking unit (2,3) to lock the expansion unit (1) in its expanded state , the locking unit (2,3) having a first element and a second element, the first and second elements of the locking unit (2,3) can be placed in locking engagement with each other when the occluding body (4, 5) is expanded, the expanding unit comprising a plurality of elongated members (1) with first and second ends each, the first end of each elongated member (1) being connected to the first element of the locking unit (2, 3) and the second and The end of each elongated member (1) is connected to the second element of the locking unit (2,3), the elongated members (1) being able to be twisted to form at least one fixation structure, the at least one being occlusive body (4,5) is a flexible sheet and the at least one occlusive body (4,5) comprises holes which are penetrated by the elongated members (1), characterized by the fact that the occluder comprises a jacket (6, 7) that involves at least a part of the expansion unit.
    [0002]
    2. Occlusor, according to claim 1, characterized by the fact that the jacket (6,7) is connected to at least one occlusive body (4,5).
    [0003]
    An occlusor according to either of claims 1 or 2, characterized in that the jacket (6,7) envelops at least one of said fixing unit.
    [0004]
    4. Occlusor according to any one of claims 1 to 3, characterized in that the occluder comprises exactly two fixing structures and two outer sheaths (6.7), each sheath (6.7) enveloping one of the fixation.
    [0005]
    5. Occlusor according to any one of claims 1 to 4, characterized in that the occluder comprises exactly a first and a second occluding body (4,5), in an unexpanded state, the first and the second occluding bodies (4,5) are arranged at a distance from each other, a first of said fixing structures being disposed between the first occlusive body (4) and the first element of the blocking unit (2,3) and a second of said fixing structures being disposed between the second occluding body (5) and the second element of the locking unit (2,3).
    [0006]
    6. Occlusor according to any one of claims 1 to 5, characterized by the fact that the expander unit (1) is movable in relation to the surrounding jacket (6,7).
    [0007]
    7. Occlusor according to any one of claims 1 to 6, characterized in that the jacket (6.7) surrounds a multiple of elongated members and the jacket (6.7) is connected to at least some of the elongated members (1), the elongated members (1) comprising a longitudinal geometric axis and the elongated members (1) can move in relation to the jacket (6,7) in the direction of its corresponding longitudinal geometric axis.
    [0008]
    8. Occlusor according to claim 7, characterized in that the jacket (6,7) is sewn on at least some of the longitudinal members (1).
    [0009]
    9. Occlusor according to any one of claims 1 to 8, characterized in that the fixing structure is expanded with the jacket (6,7).
    [0010]
    10. Occlusor according to any one of claims 1 to 11, characterized in that the occlusive body (4,5) has a circumferential edge and the jacket (6,7) is attached to the occlusive body (4, 5) at a distance from such an edge.
    [0011]
    11. Occlusor according to any one of claims 1 to 10, characterized in that the jacket (6.7) is made of a flexible material and the jacket (6.7) is compressible in a folded state.
    [0012]
    12. Occlusor, according to claim 1, characterized by the fact that a multiple of jackets (6.7) is present and envelopes at least part of the expansion unit and each elongated member is enveloped in a separate shirt from said jackets.
    [0013]
    13. Occlusor according to any one of claims 1 to 12, characterized by the fact that it comprises exactly two fixation structures and two occlusive bodies expanded by said fixation structures and the elongated members are individually enveloped at least along its length extending between the two occlusive bodies.
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    同族专利:
    公开号 | 公开日
    US9649097B2|2017-05-16|
    EP2524653A1|2012-11-21|
    US20140155932A1|2014-06-05|
    EP2709534A1|2014-03-26|
    WO2012156415A1|2012-11-22|
    JP2014521377A|2014-08-28|
    CN103533897A|2014-01-22|
    ES2640102T3|2017-10-31|
    JP6033285B2|2016-11-30|
    CN103533897B|2016-11-09|
    EP2709534B1|2017-07-19|
    BR112013029223A2|2017-03-14|
    RU2609996C2|2017-02-07|
    RU2013155032A|2015-06-27|
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    法律状态:
    2018-12-11| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2019-10-08| B06U| Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure|
    2020-08-25| B09A| Decision: intention to grant|
    2020-10-13| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/05/2012, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    EP11166363A|EP2524653A1|2011-05-17|2011-05-17|Occluder|
    EP11166363.9|2011-05-17|
    PCT/EP2012/059048|WO2012156415A1|2011-05-17|2012-05-15|Occluder|
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